منابع مشابه
Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane.
The glomerular basement membrane (GBM) is a crucial component of the kidney's filtration barrier that separates the vasculature from the urinary space. During glomerulogenesis, the GBM is formed from fusion of two distinct basement membranes, one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular endothelial cell. The main components of the GBM are laminin-...
متن کاملStages of Kidney Organogenesis
temporal coordination of numerous biomolecular interactions. Approaches geared toward elucidating the molecular and cellular basis of kidney development and branching morphogenesis have focused on the study of discrete molecules and signaling pathways by using genetic and in vitro approaches (reviewed in Refs. 11 and 71), more recently combined with microarray studies (66, 74, 75). To date, int...
متن کاملStem cells and kidney organogenesis.
The discovery of tissue stem cells has launched the current boom in the field of regenerative research, which is tremendously exciting and holds enormous therapeutic potential. Despite such optimism, recent findings have tempered the potential for medical practice. Anatomically complicated organs, such as the kidney, have proved refractory to stem cell-based regenerative techniques. As the kidn...
متن کاملSix1 is required for the early organogenesis of mammalian kidney.
The murine Six gene family, homologous to Drosophila sine oculis (so) which encodes a homeodomain transcription factor, is composed of six members (Six1-6). Among the six members, only the Six2 gene has been previously shown to be expressed early in kidney development, but its function is unknown. We have recently found that the Six1 gene is also expressed in the kidney. In the developing kidne...
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Growing new organs in situ by implanting developing animal organ primordia (organogenesis) represents a novel solution to the problem of limited supply for human donor organs that offers advantages relative to transplanting embryonic stem (ES) cells or xenotransplantation of developed organs. Successful transplantation of organ primordia depends on obtaining them at defined windows during embry...
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ژورنال
عنوان ژورنال: Organogenesis
سال: 2011
ISSN: 1547-6278,1555-8592
DOI: 10.4161/org.7.2.15275